Periarticular bone changes in rheumatoid arthritis: pathophysiological implications and clinical utility
نویسندگان
چکیده
منابع مشابه
Periarticular bone changes in rheumatoid arthritis: pathophysiological implications and clinical utility.
In recent decades there has been a dramatic change in the treatment approaches for management of rheumatoid arthritis (RA). The introduction of methotrexate and the subsequent development of the biological agents that target tumour necrosis factor (TNF) and/or immune cell activation pathways have dramatically improved patient outcomes. Nevertheless, as additional information becomes available f...
متن کاملComparing bone mineral density in rheumatoid arthritis and psoriatic arthritis
Background: Changes in patients’ bone mineral density (BMD) is one of the problems in patients with rheumatoid arthritis, which can be due to the use of corticosteroid drugs to reduce patients' symptoms or due to the aging process in patients. In this study, we decided to compare BMD in patients with psoriatic arthritis and rheumatoid arthritis. Methods: This study as a cross-sectional descrip...
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Experimental data have demonstrated that tumour necrosis factor (TNF) plays a significant role in systemic and local bone loss related to rheumatoid arthritis (RA). In clinical studies on patients with RA, treatment with TNF inhibitors was able to arrest systemic bone loss assessed by bone mineral density and bone turnover markers, but there is scarce evidence of a clinically meaningful effect ...
متن کاملA comparative study of periarticular bone lesions in rheumatoid arthritis and psoriatic arthritis.
BACKGROUND Psoriatic arthritis (PsA) and rheumatoid arthritis (RA) are both destructive arthritides but may differ substantially in their periarticular bone changes. OBJECTIVES To investigate the differences in the structural changes of periarticular bone in patients with PsA and RA by a high-resolution imaging technique designed to visualise the bone architecture. METHODS 30 patients with ...
متن کاملAssessing periarticular bone mineral density in patients with early psoriatic arthritis or rheumatoid arthritis.
BACKGROUND Periarticular osteoporosis is an early finding in the hands of patients with rheumatoid arthritis (RA), due to release of bone resorbing cytokines from the inflamed synovium. There has been disagreement as to whether periarticular bone loss occurs in psoriatic arthritis (PsA). Bone mineral density (BMD) can now be measured accurately using dual energy x ray absorptiometry (DEXA). Rec...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 2009
ISSN: 0003-4967,1468-2060
DOI: 10.1136/ard.2008.099408